Syntheses and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. III.

Various 1and 2-substituted and 1,2-fused 1,4-dihydropyridine-5-phosphonate derivatives were designed and synthesized as analogues of 1,4-dihydropyridine-3,5-dicarboxylate, and their antihypertensive activities were examined. Several compounds proved to be equal or superior to nifedipine in lowering blood pressure in normotensive and spontaneously hypertensive rats. Among these compounds, 1-substituted 1,4-dihydropyridine derivatives showed potent antihypertensive activities. The structure-activity relationships are discussed.